This is a Nuzlocke variant I created. This can only be played in games with Mewtwo, hence the name.
Mewtwo has sensed a strong Trainer come to its region, and has cursed him/her by only letting this Trainer catch the first Pokémon in the area and boxing any fainted Pokémon. Defeating Mewtwo will lift this curse and you will be free!
-If a Pokémon faints, it gets put in the "Fainted" box.
-Other caught Pokémon get put in the "Other Teammates"/"Non Fainted" box.
-HM Slaves can be used for HMs only. Not in battle. Also, HM Slaves can be used even if they faint, but only if they are still needed.
-First catch rule, like always
-First catch rule exception: If your first encounter is the same type as your starter (Grass, Fire, Water), then you can either catch it OR get 3 chances to get a non-same type Pokémon.
-After beating ALL Gym Leaders, you can heal all your Fainted Pokémon. The same applies to the E4 and Champion.
-With your full team, take on Mewtwo. You MUST defeat it. If you win, then the curse is lifted and you no longer have to play as a Nuzlocke.
-Also, if you EVER lose your Starter, it's Game Over. Whenever you black/white out, it's also Game Over.
-Dupes clause is on.
-TMs only after 4th badge.
-Healing items are allowed. Obviously no Revives/Max Revives.
Some parts I find are easier than normal Nuzlocke and some parts I find are harder.
Please try out and review in the comments!